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Erectile dysfunction (ED)

Erectile dysfunction (ED), also known as impotence, is the inability to achieve or sustain an erection for satisfactory sexual activity. Erectile dysfunction is different from other conditions that interfere with sexual intercourse, such as lack of sexual desire and problems with ejaculation and orgasm. This article focuses on the evaluation and treatment of erectile dysfunction.

How common is erectile dysfunction?

Erectile dysfunction (ED, impotence) varies in severity; some men have a total inability to achieve an erection, others have an inconsistent ability to achieve an erection, and still others can sustain only brief erections. The variations in severity of erectile dysfunction make estimating its frequency difficult. Many men also are reluctant to discuss erectile dysfunction with their doctors, and thus the condition is under-diagnosed. Nevertheless, experts have estimated that erectile dysfunction affects 30 million men in the Untied States.

 

Sildenafil (Viagra)

What is sildenafil (Viagra)?

Sildenafil (Viagra) was the first oral phosphodiesterase type 5 (PDE5) inhibitor approved by the FDA in the United States for the treatment of erectile dysfunction (it is not approved for women). Sildenafil inhibits PDE5, which is an enzyme that destroys cGMP. By inhibiting the destruction of cGMP by PDE5, sildenafil allows cGMP to accumulate. The cGMP in turn prolongs relaxation of the smooth muscle of the corpora cavernosa. Relaxation of the corpora cavernosa smooth muscle allows blood to flow into the penis resulting in increased engorgement of the penis. In short, sildenafil increases blood flow into the penis and decreases blood flow out of the penis.

Vardenafil (Levitra)

What is vardenafil (Levitra)?

Vardenafil (Levitra) was the second oral medicine approved by the United FDA in the S for the treatment of erectile dysfunction. Like sildenafil (Viagra), vardenafil (Levitra) inhibits PDE5 which destroys cGMP (as discussed earlier).

How effective is vardenafil (Levitra)?

In all four studies, vardenafil was significantly better than placebo in improving men's ability to achieve and maintain erections in all age categories (less than 45, 45-65,and greater than 65 years of age) and in all races.

 

Tadalafil (Cialis)

What is tadalafil (Cialis)?

Tadalafil (Cialis) is the third oral medicine approved by the United FDA in the US for the treatment of erectile dysfunction. Like sildenafil (Viagra) and vardenafil (Levitra), tadalafil inhibits PDE5 (as described earlier).

How effective is tadalafil (Cialis)?

The safety and efficacy of tadalafil in the treatment of erectile dysfunction was evaluated in 22 clinical trials involving more than 4,000 men. Seven of these trials were randomized, prospective, placebo-controlled studies of 12 weeks' duration. Two of these studies (involving 402 men) were conducted in the Untied States, and the other five studies (involving 1112 men) were conducted outside the Untied states. Two of these trials were conducted in special erectile dysfunction populations; one in men with diabetes mellitus, another in men who developed erectile dysfunction after nerve-sparing prostate cancer surgery.

Tadalafil is rapidly absorbed after oral administration and the mean maximum observed plasma concentration is achieved at a median time of 2 hours after dosing. Absolute bioavailability of tadalafil following oral dosing has not been determined. The rate and extent of absorption of tadalafil are not influenced by food, thus CIALIS may be taken with or without food. The time of dosing (morning versus evening) had no clinically relevant effects on the rate and extent of absorption.

 

Vigrx

Vigrx is doctor approved penis enlargement formula used by millions of men for enlarging their penis and have good sex life. Generally vigrx is mispelles as viagrx also.

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Semenax is a herbal male sexual booster, It increases semen volume and intensity of orgasm many times. It is generally mispelled as semanax also

Cialis is the recently found drug for erectile disfunction and extensively resaerched and studied drug for treating erectile disfunction. It lasts in the body for more than 36 hours and so the half life of cialis in the body keeps on increasing and so sexual activity at any time is conveniently possible for those taking cialis. Not like viagra - for viagra it needs about 4 hours after takinh the pills. With Cialis it takes only 15 minutes for the onset of action.


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