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What is sildenafil (Viagra)?

Sildenafil (Viagra) was the first oral phosphodiesterase type 5 (PDE5) inhibitor approved by the FDA in the United States for the treatment of erectile dysfunction (it is not approved for women). Sildenafil inhibits PDE5, which is an enzyme that destroys cGMP. By inhibiting the destruction of cGMP by PDE5, sildenafil allows cGMP to accumulate. The cGMP in turn prolongs relaxation of the smooth muscle of the corpora cavernosa. Relaxation of the corpora cavernosa smooth muscle allows blood to flow into the penis resulting in increased engorgement of the penis. In short, sildenafil increases blood flow into the penis and decreases blood flow out of the penis. Sildenafil is used for the treatment of erectile dysfunction of either physical or psychological cause.

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The drugs used to treat erectile disfunction are

• Cialis, commonly mispelled as Cialas, Cialix, Cyalis, Cailis, Cealis

• Levitra, commonly mispelled as Lavetra, Lavitra, Levetra, Livetra, Livitra

• Viagra, commonly mispelled as Vagara, Viagara, Viagera, Viegra, Vigara

The sexual supplements used to boost sexual desire and penis sixe are

• Vigrx, mispelled as Viagrx

• Semenax, mispelled as Semanax

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